How to Make Ketamine


Ketamine was first synthesized in 1962 in an attempt to find a safer anaesthetic alternative to Phencyclidine (PCP), which was more likely to cause hallucinations and seizures. The drug was first given to American soldiers during the Vietnam War, but today in the developed world its use on humans has been dramatically curtailed because of exaggerated concern about its potential to cause emergence phenomena including out of body experiences in clinical practice. Patients have reported vivid hallucinations, “going into other worlds” or “seeing God” while anaesthetized, and these unwanted psychological side-effects have reduced the use of ketamine in human medicine. However, it is still used widely in veterinary medicine, or as a battlefield anesthetic in developing nations. – Wiki

This is an old text file I had in my archives. I cannot verify the chemistry since I do not produce ketamine nor am I a chemist. This is being posted for educational research purposes only. – drugnerd


Synthesis of Ketamine




1-Hydroxycyclopentyl-(o-chlorophenyl)-ketone N-methylimine
To the grignard reagent prepared from 119.0 g of cyclopentyl bromide and 19.4 g of magnesium is added 55.2 g of o-chlorobenzonitrile. The reaction mixture is stirred for three days and thereafter hydrolyzed in the usual manner. From the hydrolysis there is obtained o-chlorophenylcyclopentylketone, bp 96-97°C (0.3 mmHg). To 21.0 g of the ketone is added 10.0 g of bromine in 80 ml of CCl4. 1-bromocyclopentyl-(o-chlorophenyl)-ketone, bp 111-114°C (0.1 mmHg) is isolated in the usual manner. Since it is unstable, it must be used immediately. The bromoketone (29.0g) is dissolved in 50 ml of liquid methylamine freebase. After one hour, the excess liquid methylamine is allowed to evaporate. The organic residue is dissolved in pentane, and upon evaporation of the solvent, 1-hydroxy-cyclopentyl-(o-chlorophenyl)-ketone N-methylimine is isolated, mp 62°C.


2-Methylamino-2-(o-chlorophenyl)-cyclohexanone (Ketamine)
1-hydroxycyclopentyl-(o-chlorophenyl)-ketone N-methylimine (2.0 g) is dissolved in 15 ml of decalin and refluxed for 2.5 h. After evaporation of the decalin under reduced pressure, the residue is extracted with dilute hydrochloric acid, the solution treated with decolorizing charcoal, and the resulting acidic solution is made basic. The liberated product, 2-methylamino-2-(o-chlorophenyl)-cyclohexanone (Ketamine), after recrystallization from pentane-ether, has a mp of 92-93°C. The hydrochloride has a mp of 262-263°C.



{ 11 comments to read ... please submit one more! }

  1. By “my archives” you mean, right?

  2. When I say “my archives” I am talking about a folder on my network that I have been saving text files to for years. Thanks for sharing the link though.

  3. does not have this file

  4. No I think you mean, because the information you posted is word for word from a file posted on fidonet in the early nineties and archived on Cite your sources.

  5. This is very unreliable, we all know that Methylamino can not be heated over 45.98 degrees.
    Goodness people, learn something about drugs!

  6. Dumb people say dumb words.

    > Cite your sources.
    If you are so smart, then you’d at least understand that
    the writer had clearly hinted that the source is not known.

    > Goodness people, learn something about drugs!
    The writer clearly said not being a chemist nor a ketamine maker.
    You should learn something about English first before asking others
    to learn about drugs.

  7. goodness people. why learn about drugs. do something else worthwhile in life. i know, i know, everyone’s gonna freak at me and scream their head off when I post this. but even with all the odd against me, i suggest everyone go do something else. and for your information, I’m on this website because I was researching for a ”Special K” project

  8. sounds like ya’ll all need some ketamine…..arguing over this and that….if you can make it, then make it….if not, shut the fuck up

  9. i would recommend it to all ages.

  10. You guys are all retards

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